Curcumin and Curcuminoids in the Treatment of Inflammatory Bowel Diseases

Curcumin inhibits a number of enzymes that are involved  in the synthesis of inflammatory chemical modulators. Curcumin has been recognized as an anti-inflammatory agent as well as a pain reliever.  Research studies have demonstrated that the anti-inflammatory activity of curcumin is comparable in strength to steroidal and non-steroidal prescription medications. TNF-alpha elevation is an important component of the inflammatory process,  involved in the pathogenesis of many inflammatory disorders, including Crohn’s Disease, Irritable Bowel, rheumatoid and lupus.

Curcumin, a flavonoid from the herb turmeric is a well studies known inhibitor of TNF-alpha. Studies have demonstrated that TNF-alpha increased intestinal permeability and curcumin inhibited the NFkappa Beta- induced-TNF-alpha-stimulated increase in intestinal ‘leakiness.’

Curcumin inhibits several of the cytokines and genes involved in the pathogenesis of inflammatory bowel disease, and curcumin down regulates or shuts down the production of  several pro-inflammatory prostaglandins and leukotrienes.

Inflammation results from a complex cascade of chemical changes that are triggered by  responses to tissue damage.  Chronic inflammation leads to degenerative conditions like arthritis, arteriosclerosis, etc.

The rate, route and amount of administration of curcumin will depend entirely on the gender, age and other disease states that may exist in a patient.  Curcumin is very inexpensive, but it must be taken properly for it to be most effective.  We keep it in the office for our patients, but it is in our catalogue, as well.

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About David S Klein, MD 149 Articles
David S. Klein, MD, FACA, FACPM was born in Washington, DC, and was raised in Chevy Chase, Maryland. He completed his undergraduate education at the University of Maryland with degrees in Chemistry and Psychology. Medical School was completed at the University of Maryland at Baltimore, followed by Internship in General Surgery at the University of North Carolina and Residency in Anesthesiology at the Duke University, Durham, North Carolina. Dr Klein has been practicing medicine since 1983, concentrating in Pain Medicine, Minimally Invasive Medicine and Surgery, and Neuroendocrinology. Earning Board Certification in Anesthesiology, Dr. Klein was elected Fellow in the American College of Anesthesiology, and he was elected Fellow in the American College of Pain Medicine. He is currently an adjunct Associate Professor at the University of Central Florida, School of Medicine. He has focused his private practice on treating patients with hormone imbalance issues, nutritional deficiency related medical problems as well as pain related issues and impairment. With a highly-complex, CLIA licensed laboratory in-house, he has been able to provide rapid-turn around analysis efficiently and cost-effectively. Lecturing extensively nationally as well as internationally, Dr. Klein has authored many articles on topics relating to pain, injury and nutritionally modulated illness. His radio show, “Pain Free Living,” received top ratings during the 6 years it was on the air. Currently practicing in Longwood, Florida, Dr. Klein practices entirely in the office setting.