J Cardiovasc Pharmacol. 2007 Jul;50(1):41-9.
Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.
Heart Center of Chonnam National University Hospital, Gwangju, South Korea.
a yellow pigment of turmeric in curry, is reported to interfere with
nuclear factor (NF)-kappaB. This study was designed to investigate the
underlying pathway of antiinflammation of curcumin on endothelial
cells. Human umbilical vein endothelial cells (HUVECs) were stimulated
with 10 ng/mL tumor necrosis factor (TNF)-alpha. Curcumin blocked the
activation of NF-kappaB by TNF-alpha. Curcumin also reduced the
intracellular reactive oxygen species (ROS), monocyte adhesion,
phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal
transducer and activator of transcription (STAT)-3 in
TNF-alpha-stimulated HUVECs. The expression of intracellular cell
adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1,
and interleukin (IL)-8 were attenuated by curcumin at both mRNA and
protein level. Curcumin, however, did not affect the expression of TNF
receptor I and II in TNF-alpha-stimulated HUVECs. We suggest that
curcumin could contribute to protection against the adverse vascular
effect of the proinflammatory response through the modulation of p38
and STAT-3 in addition to NF-kappaB and JNK in endothelial cells.