Curcumin is a potent anti-oxidant. Useful for protection of cardio vascular system.

J Cardiovasc Pharmacol. 2007 Jul;50(1):41-9.

Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.

Kim YS, Ahn Y, Hong MH, Joo SY, Kim KH, Sohn IS, Park HW, Hong YJ, Kim JH, Kim W, Jeong MH, Cho JG, Park JC, Kang JC.

Heart Center of Chonnam National University Hospital, Gwangju, South Korea.

Curcumin,
a yellow pigment of turmeric in curry, is reported to interfere with
nuclear factor (NF)-kappaB. This study was designed to investigate the
underlying pathway of antiinflammation of curcumin on endothelial
cells. Human umbilical vein endothelial cells (HUVECs) were stimulated
with 10 ng/mL tumor necrosis factor (TNF)-alpha. Curcumin blocked the
activation of NF-kappaB by TNF-alpha. Curcumin also reduced the
intracellular reactive oxygen species (ROS), monocyte adhesion,
phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal
transducer and activator of transcription (STAT)-3 in
TNF-alpha-stimulated HUVECs. The expression of intracellular cell
adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1,
and interleukin (IL)-8 were attenuated by curcumin at both mRNA and
protein level. Curcumin, however, did not affect the expression of TNF
receptor I and II in TNF-alpha-stimulated HUVECs. We suggest that
curcumin could contribute to protection against the adverse vascular
effect of the proinflammatory response through the modulation of p38
and STAT-3 in addition to NF-kappaB and JNK in endothelial cells.

David S Klein, MD

David S. Klein, MD, FACA, FACPM was born in Washington, DC, and was raised in Chevy Chase, Maryland. He completed his undergraduate education at the University of Maryland with degrees in Chemistry and Psychology.

Medical School was completed at the University of Maryland at Baltimore, followed by Internship in General Surgery at the University of North Carolina and Residency in Anesthesiology at the Duke University, Durham, North Carolina. Dr Klein has been practicing medicine since 1983, concentrating in Pain Medicine, Minimally Invasive Medicine and Surgery, and Neuroendocrinology. Earning Board Certification in Anesthesiology, Dr. Klein was elected Fellow in the American College of Anesthesiology, and he was elected Fellow in the American College of Pain Medicine. He is currently an adjunct Associate Professor at the University of Central Florida, School of Medicine.

He has focused his private practice on treating patients with hormone imbalance issues, nutritional deficiency related medical problems as well as pain related issues and impairment. With a highly-complex, CLIA licensed laboratory in-house, he has been able to provide rapid-turn around analysis efficiently and cost-effectively.
Lecturing extensively nationally as well as internationally, Dr. Klein has authored many articles on topics relating to pain, injury and nutritionally modulated illness. His radio show, “Pain Free Living,” received top ratings during the 6 years it was on the air. Currently practicing in Longwood, Florida, Dr. Klein practices entirely in the office setting.

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