Low Testosterone; 041915 Hour 2


I have a high estradiol level, and a low testosterone level. 158 and 328, respectively. I have not been receiving any testosterone products thus far. What is happening, and how can I fix it?


To fix this is simple. To treat this issue, we would give you transdermal testosterone to bring that hormone level up. In the testosterone transdermal, I would add something called chrysin and progesterone. The reason for that is these aromatase and 5-alpha reductase inhibitors block the degradation of testosterone to estradiol. Then, in the meantime, I would start you on an oral medication called anastrozole, and that will further block the degradation of testosterone to estradiol.

Why would you end up this way? An enzyme, called aromatase, reduces testosterone to estradiol. Something peculiar is going on with your degradation of testosterone to estradiol.
The other thing you can do is increase your excretion of the estradiol. This is really easy. We do it using a combination of silymarin and curcumin. Silymarin is milk thistle, and it causes the gall bladder to excrete these estrogen esters into your small bowel. Along with that, you take something called insoluble fiber, taken as capsules, or you can get fiber bars. It doesn’t really matter. Then the estradiol and cholesterol will adhere to the insoluble fiber, and it goes out with the bowel.

The fix is simple: you just have to block aromatase. This is not big deal. This is neuroendocrine 101.

In summary, I would be focusing on two things. One, the excretion of the estradiol, and the other one is blocking the degradation.

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About David S Klein, MD 149 Articles
David S. Klein, MD, FACA, FACPM was born in Washington, DC, and was raised in Chevy Chase, Maryland. He completed his undergraduate education at the University of Maryland with degrees in Chemistry and Psychology. Medical School was completed at the University of Maryland at Baltimore, followed by Internship in General Surgery at the University of North Carolina and Residency in Anesthesiology at the Duke University, Durham, North Carolina. Dr Klein has been practicing medicine since 1983, concentrating in Pain Medicine, Minimally Invasive Medicine and Surgery, and Neuroendocrinology. Earning Board Certification in Anesthesiology, Dr. Klein was elected Fellow in the American College of Anesthesiology, and he was elected Fellow in the American College of Pain Medicine. He is currently an adjunct Associate Professor at the University of Central Florida, School of Medicine. He has focused his private practice on treating patients with hormone imbalance issues, nutritional deficiency related medical problems as well as pain related issues and impairment. With a highly-complex, CLIA licensed laboratory in-house, he has been able to provide rapid-turn around analysis efficiently and cost-effectively. Lecturing extensively nationally as well as internationally, Dr. Klein has authored many articles on topics relating to pain, injury and nutritionally modulated illness. His radio show, “Pain Free Living,” received top ratings during the 6 years it was on the air. Currently practicing in Longwood, Florida, Dr. Klein practices entirely in the office setting.