Omega 3 – Update

Environmental, cultural and practical changes in the industrialized world have resulted in alterations in dietary habits that have had interesting, if not life-threatening implications.  The human physiology has remained relatively unchanged for tens of thousands of years- diet remaining relatively unchanged, but for the periodic and unpredictable famine. Rather suddenly, rapid and remarkable dietary changes occurred.

 Diets rich in fiber, complicated carbohydrates and omega-3 fatty acids were changed to diets poor in fiber, rich in simple carbohydrates and rich in omega-6 fatty acids.  Replacement of simple carbohydrates for the more natural complicated carbohydrates introduces a vulnerability to diabetes, obesity, autoimmune disorders and vascular disease.  Replacement of omega-6 fatty acids for omega-3 fatty acids introduces a vulnerability to inflammatory diseases, vascular diseases and cancer.

The Problem

The human diet influenced human physiology for many thousands of years before the modern age.  Omega-3 and omega-6 fatty acids had been consumed through a combination of vegetable and animal sources resulting in a rather stable ratio between the two classes of oils.  The Western Diet, however, changed, resulting in an increase in the amount of omega-6 fatty acids and a steady decline in the amount of omega-3’s.  As it were, maintenance of the ratio was important for reasons more subtle than simple caloric intake.

Given the fact that the Western Diet has increased omega-6 (pro-inflammatory) fatty acids relative to the omega-3 (anti-inflammatory) fatty acids, the intake of these EFA’s can be adjusted to restore a more normal ratio through the reduction of omega-6’s and the introduction of omega-3 fatty acids. 


Distilled to the essence, the problem is systemic inflammation.  While this may sound a bit simplistic, most elegant problems and elegant solutions are simple in nature. Omega-6 fatty acids metabolize into pro-inflammatory modulators known as prostaglandins and  leukotrienes.  The Omega-3 fatty acids metabolize into anti-inflammatory modulators known as resolvins and protectins. 

Resolvins are compounds metabolized from the  omega-3 fatty acids eicosapentanaeic acid (EPA), and docosahexanoic acid (DHA).   They are produced by through the cyclo-oxygenase  pathway, increased in the presence of  aspirin. Resolvins reduce cellular inflammation by inhibiting the production and transportation of inflammatory cells. Compounds derived from EPA are designated as resolvins of the E series, while those formed from the precursor DHA are denoted as either resolvins or protectins (formerly ‘neuroprotectins’ of the D series.)

Interaction of Omega-3 Fatty Acids and Aspirin

The resolvins and neuroprotectins are distinctive compounds. These lipids are strong anti-inflammatory agents, with immunoregulatory activities at very low concentrations. They are involved in molecular mechanisms that regulate and modulate removal of inflammatory cells and  cell byproducts.  They restore of tissue integrity once the immediate need for an inflammatory response has ended.

Through actions involving resolvins and protectins, aspirin facilitates the resolution of inflammation. At local sites of inflammation, aspirin enhances the conversion of the omega-3 fatty acids EPA and DHA to 18Roxygenated products, resolvins of the E and D series, which are potent anti-inflammatory agents. Low dose aspirin, combined with omega-3 fatty acids is an extremely potent anti-inflammatory combination.


        At this time, in our current social environment, it is very, very difficult to dramatically reduce the amount of omega-6 in our diet. To restore the balance of the 3:6 ratio, it is far easier and faster to increase the intake of omega-3’s. 

1.    Distilled (mercury-free) fish oil, 1,000 to 2,000 mg twice daily.

2.    Olive Oil- 1 ounce daily. 

3.    Aspirin 82 to 164 mg per day.

4.    For diabetics- add Alpha Lipoic Acid 250 mg 3 times, daily.

There are many good quality fish oils on the market.  Unfortunately, there are many more poor-quality products available.  Getting high quality does not necessarily take a great deal of expense, but you rarely get quality ‘on the cheap.’

We use (coincidentally) our line of products by ‘Stages of Life, Inc.’  These are pharmaceutical grade, and offer a good value.

1.      Heart & Sole- bottles of 120                       

2.      Alpha Lipoic Acid 250 mg- bottles of 120    

The Olive Oil can be obtained at the grocery store, as can a good quality aspirin (I prefer St Joseph’s Baby Aspirin). 

About David S Klein, MD 149 Articles
David S. Klein, MD, FACA, FACPM was born in Washington, DC, and was raised in Chevy Chase, Maryland. He completed his undergraduate education at the University of Maryland with degrees in Chemistry and Psychology. Medical School was completed at the University of Maryland at Baltimore, followed by Internship in General Surgery at the University of North Carolina and Residency in Anesthesiology at the Duke University, Durham, North Carolina. Dr Klein has been practicing medicine since 1983, concentrating in Pain Medicine, Minimally Invasive Medicine and Surgery, and Neuroendocrinology. Earning Board Certification in Anesthesiology, Dr. Klein was elected Fellow in the American College of Anesthesiology, and he was elected Fellow in the American College of Pain Medicine. He is currently an adjunct Associate Professor at the University of Central Florida, School of Medicine. He has focused his private practice on treating patients with hormone imbalance issues, nutritional deficiency related medical problems as well as pain related issues and impairment. With a highly-complex, CLIA licensed laboratory in-house, he has been able to provide rapid-turn around analysis efficiently and cost-effectively. Lecturing extensively nationally as well as internationally, Dr. Klein has authored many articles on topics relating to pain, injury and nutritionally modulated illness. His radio show, “Pain Free Living,” received top ratings during the 6 years it was on the air. Currently practicing in Longwood, Florida, Dr. Klein practices entirely in the office setting.