Phosphoric Acid, Vitamin K-2

Dietary influences that increases
bone demineralization are becoming more and more problematic. Intake of phosphoric acid, as an example, can
dramatically accelerate the development of osteoporosis. Cola beverages are the
greatest risk in this regard. Phosphoric acid is present in high concentration
in cola beverages, and with intake of these soft-drinks, excretion of the
phosphate moiety takes place in the
form of calcium phosphate. With intake of excessive amounts of phosphoric acid,
drinking cola beverages may hasten the development of osteoporosis by  worsening  calcium deficiency in the bone itself, which in
turn causes weakening of the  teeth and
weak bone density (osteoporosis).2

FACT: Phosphoric acid intake, in the form of
carbonated soft-drinks can hasten the development of osteoporosis.

Vitamin K-2

Vitamin K is a lesser known
vitamin group, composed of three major chemicals, structurally similar,
fat-soluble, 2-methyl-l,4-naphthoquinones, including phylloquinone (K1),
menaquinones (


), and menadione (K3).

Vitamin K2 (menaquinone), stimulates bone formation by way of
hormone-regulation. This is thought to
consist of gamma-carboxylation of osteocalcin and/or steroid and xenobiotic
receptors (SXRs). This modulation
reduces the incidence of vertebral fractures, despite having only modest direct
effects on the bone mineral density (BMD).4


The most common form of vitamin K2 in animals is
menaquinone 4 (menatetrenone; MK-4), produced by the processing of exogenous
and bacterial naphthoquinones
 Vitamin K is a
coenzyme for glutamate carboxylase, an enzyme which mediates the conversion of
the amino acid glutamate to gamma-carboxyglutamate (Gla). The
gamma-carboxylation of the these proteins is essential for the proteins to
attract calcium, and to incorporate calcium into the hydroxyapatite crystals
that form bone.6

Vitamin K-2 is found in certain
vegetables, but it is absorbed best if injested simultaneously with butter.
Further, the production of Vitamin K-2 is accomplished through ‘normal’
gastro-intestinal bacteria.

NOTE WELL: Supplementation of
vitamin K-2 can prevent the development of osteoporosis and reduce the risk of
lumbar compression fractures from osteoporosis.8


FACT #1: Marjorine is not butter, and marjorine is
consumed in far greater amounts than butter, thereby reducing available Vitamin
K2 in our diet.

FACT #2: Gastrointestinal flora are important to the
production of Vitamin K2. Anti-biotics kill off the ‘good bacteria’
right along with the pathogenic bacteria. Patients demand anti-biotics for all
manners of problems that would best be treated without anti-biotics. By altering gastrointestinal bactial flora,
we are crippling our ability to get K-2, thereby worsening our skeletal

FACT #3: Taking the wrong form or
formulation of Vitamin K, or Vitamin K-2 is worthless in therapeutic
benefit. You’ve got to know your
chemistry, here.

About David S Klein, MD 149 Articles
David S. Klein, MD, FACA, FACPM was born in Washington, DC, and was raised in Chevy Chase, Maryland. He completed his undergraduate education at the University of Maryland with degrees in Chemistry and Psychology. Medical School was completed at the University of Maryland at Baltimore, followed by Internship in General Surgery at the University of North Carolina and Residency in Anesthesiology at the Duke University, Durham, North Carolina. Dr Klein has been practicing medicine since 1983, concentrating in Pain Medicine, Minimally Invasive Medicine and Surgery, and Neuroendocrinology. Earning Board Certification in Anesthesiology, Dr. Klein was elected Fellow in the American College of Anesthesiology, and he was elected Fellow in the American College of Pain Medicine. He is currently an adjunct Associate Professor at the University of Central Florida, School of Medicine. He has focused his private practice on treating patients with hormone imbalance issues, nutritional deficiency related medical problems as well as pain related issues and impairment. With a highly-complex, CLIA licensed laboratory in-house, he has been able to provide rapid-turn around analysis efficiently and cost-effectively. Lecturing extensively nationally as well as internationally, Dr. Klein has authored many articles on topics relating to pain, injury and nutritionally modulated illness. His radio show, “Pain Free Living,” received top ratings during the 6 years it was on the air. Currently practicing in Longwood, Florida, Dr. Klein practices entirely in the office setting.