Supplemental cholecalciferol (vitamin D) significantly
reduces all-cause mortality emphasizes the medical, ethical, and legal
implications of promptly diagnosing and adequately treating vitamin D
deficiency. Vitamin D deficiency is common, and is implicated in most of the diseases of
Vitamin D-3 is a steroidal hormone that targets
more than 200 human genes in a wide variety of tissues. With genes
asits target, vitamin D has been shown to up-regulate the gene that is
in volved in the production of cathelicidin, a naturally
occurring broad-spectrum antibiotic.
of vitamin D deficiency, in otherwise healthy persons involves dosages
between 2,000-7,000 IU vitamin D-3, daily. With serious systemic
illnesses, associated with vitamin D deficiency, such as cancer,
heart disease, multiple sclerosis, diabetes, autism, the doses should
be somewhat higher to maintain 25(OH)D levels between 55 -70 ng per mL.
Vitamin D-deficient patients
with serious illness should not only be supplemented more aggressively
than the well, they should have more frequent monitoring of serum
25(OH)D and serum calcium.
Doses of vitamin D-3 (2,000 IU
per kg per day for three days) may produce enough of the naturally
occurring antibiotic cathelicidin to cure common viral respiratory
infections, such as influenza and the common cold, but such a theory
awaits further science. This is a very high dosage regimen. For
general use, Vitamin D-3 dosages of 2,000 to 5,000 IU are sufficient to
enhance immune function and minimize flu symptoms, if exposed to the
D-3 is very inexpensive, about $4 per month. Because Vitamin D-3 is
oil-soluble, it must be taken with an oil capsule, of almost any type.
David S. Klein, MD, FACA, FACPM is the Medical Director of
the Pain Center of Orlando, Inc. A graduate
of the University of Maryland School of Medicine, Dr. Klein received training
in General Surgery at the University of North Carolina, and Anesthesiology
at Duke University
Dr. Klein has been in private practice for 25 years and is
a well published author, lecturing regionally and nationally on topics ranging
from nutritional intervention, hormone replacement and pain treatment.