The Many Advantages of adding Hyaluronic Acid: A Comprehensive Discussion of Cardiac and Gastrointestinal Benefits, chronic disease treatment and prevention.

David S. Klein, MD FACA FACPM

Feb 285 min read

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found in the extracellular matrix of connective tissues, particularly in the skin, joints, and eyes. It plays a critical role in maintaining hydration, lubrication, and structural integrity in these tissues. Supplementing with HA has gained significant popularity due to its numerous health benefits, particularly in dermatology, rheumatology, and ophthalmology. This discussion explores the advantages of HA supplementation and provides visual representations of its impact on the human body.

the molecular structure of Hyaluronic Acid, depicting its repeating disaccharide units. — The chemical structure of High Molecular Weight Hyaluronic Acid

1. Enhanced Skin Hydration and Anti-Aging Effects

One of the most well-known benefits of HA supplementation is its ability to improve skin hydration. HA molecules can hold up to 1,000 times their weight in water, helping to retain moisture in the skin. Clinical studies have shown that oral HA supplementation improves skin hydration and elasticity, reducing the appearance of wrinkles and fine lines. By reinforcing the skin barrier, HA also protects against environmental stressors such as pollution and UV radiation.

2. Reduction of Wrinkles and Increased Skin Elasticity

As we age, HA levels in the skin diminish, leading to dryness and loss of elasticity. Supplementing with HA has been found to stimulate collagen production, which helps maintain skin firmness and elasticity. A 12-week clinical trial demonstrated that individuals who took HA supplements experienced significant reductions in wrinkle depth and overall skin smoothness compared to those who did not.

Lubrisyn is a liquid product that contains high molecular weight, long chain hyaluronic acid. Best taken 1 tablespoon every morning, it can also be used by adding a few drops to your favorite moisturizing lotion, and apply before bed. The liquid concentrate provides the best long-chain HA. The capsular form has value but it is not nearly as effective as is the liquid form, above.

3. Joint Lubrication and Arthritis Relief

HA is a crucial component of synovial fluid, which lubricates and cushions joints. In individuals with osteoarthritis, HA levels decline, leading to joint pain and stiffness. Clinical trials have shown that HA supplementation can alleviate symptoms of osteoarthritis by improving joint lubrication and reducing inflammation. Many patients report reduced pain and increased mobility after consistent HA intake.

4. Acceleration of Wound Healing

HA plays a vital role in tissue repair and wound healing. It promotes cell migration and proliferation, which are necessary for wound closure. Additionally, HA has anti-inflammatory and antibacterial properties, helping to prevent infections and accelerate the healing of cuts, burns, and ulcers. Studies have confirmed that HA-based treatments speed up the healing process in diabetic foot ulcers and postoperative wounds.

5. Improved Eye Health and Dry Eye Syndrome Treatment

HA is abundant in the vitreous humor of the eye, where it helps maintain eye hydration and structure. Patients with dry eye syndrome benefit from HA supplementation, as it enhances tear film stability and reduces eye irritation. HA-based eye drops are widely used to alleviate symptoms of dry eye disease, but oral HA supplements also contribute to ocular hydration.

6. Gut Health and Digestive Support

Emerging research suggests that HA benefits the digestive system by supporting gut lining integrity. It plays a role in reducing inflammation in conditions like irritable bowel syndrome (IBS) and leaky gut syndrome. HA supplementation may enhance intestinal barrier function, preventing the translocation of harmful bacteria and reducing overall gut permeability.

Hyaluronic acid supports gastrointestinal health by improving the Glycocalyx protection that covers the entirety of the GI tract.

7. Immune System Modulation

HA interacts with immune cells, modulating inflammation and immune responses. It can help reduce chronic low-grade inflammation, which is associated with aging and various diseases. HA's ability to regulate inflammatory pathways may have implications for conditions such as rheumatoid arthritis, asthma, and autoimmune disorders.

8. Supports Hair Growth and Scalp Health

HA supplementation has been found to improve hair hydration and follicular function. By increasing scalp moisture and reducing inflammation, HA helps create a healthier environment for hair growth. Some studies suggest that HA combined with other nutrients can enhance hair thickness and reduce shedding.

9. Cardiovascular Benefits

HA is present in blood vessels and contributes to vascular elasticity and function. Research indicates that HA supplementation may support endothelial cell health, reducing arterial stiffness and improving circulation. Some studies suggest that HA may play a role in lowering blood pressure and enhancing overall cardiovascular health.

Again, hyaluronic acid is beneficial to the peripheral vascular system and heart by enhancing the innermost lining of the entire cardiovascular system. It supports, stimulates repair and maintenance fo the glycocalyx layer, which lines the entire cardiovascular system, the gut and other important systems.

10. Safety and Dosage Considerations for Long chain hyaluronic acid for cardiac and gastrointestinal complaints.

HA supplementation is generally well-tolerated with minimal side effects. It is available in various forms, including capsules, powders, and liquid formulations. The typical recommended daily dosage ranges from 120 mg to 240 mg. Clinical trials have demonstrated its safety for long-term use, making it a viable option for those seeking to improve skin health, joint function, and overall well-being.

Instructions for using hyalaluronic acid for cardiac and gastrointestinal conditions.

NOTE: Take the Lubrisyn as follows: 1 Tablespoon every morning with your daily routine. It is a little sweet, easily consumed right off of a spoon, or it can be put on top of your breakfast food. Not best to put it on hot foods, as it may denature the HA, I put mine on my cottage cheese, yogurt or toast.

Adding Lubrisyn to your daily regime will cost a bit less than $1 per day, and it adds tremendous benefits for the little cost involved.

Scientific References

Kawada, C., Yoshida, T., & Yoshida, H. (2014). Effects of oral hyaluronan on wrinkles and skin condition. Journal of Clinical Biochemistry and Nutrition, 56(1), 66–73.
Oe, M., & Tashiro, T. (2017). Oral hyaluronan enhances skin hydration: A randomized, double-blind, placebo-controlled study. Nutrition Journal, 16, 1-9.
Henrotin, Y., Lambert, C., Richette, P. (2015). Importance of hyaluronic acid in osteoarthritis treatment. Clinical and Experimental Rheumatology, 33(4), 70-75.
Wang, Y., Liao, Y., & Li, Y. (2020). Role of hyaluronic acid in wound healing: A review. Journal of Tissue Engineering and Regenerative Medicine, 14(6), 881–892.
Aragona, P., & Rolando, M. (2013). Hyaluronic acid and the treatment of dry eye disease. Clinical Ophthalmology, 7, 1-10.
Mine, S., Okumura, T., & Tanaka, Y. (2016). Hyaluronic acid as an immune modulator in inflammatory diseases. Journal of Inflammation Research, 9, 116-122.
Sato, N., Taniguchi, T., & Kikuchi, Y. (2019). Effect of hyaluronic acid on hair growth in patients with androgenetic alopecia. Journal of Dermatological Science, 93(2), 139–146.
Ghosh, P., & Guidolin, D. (2002). Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: Are the effects molecular weight dependent? Seminars in Arthritis and Rheumatism, 32(1), 10-37.
Farr, J. N., & Khosla, S. (2019). Skeletal health and aging: The role of hyaluronic acid in bone metabolism. Current Osteoporosis Reports, 17(5), 236-245.
Litwiniuk, M., Krejner, A., & Grzela, T. (2016). Hyaluronic acid in inflammation and tissue regeneration. Wounds, 28(3), 78-88.