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  • David S. Klein, MD FACA FACPM

Berberine: The Best Herbal Supplement for Diabetes, Prevent Cancer, and even more......

Best Supplement for diabetes and weight loss
Berberine for Diabetes

Berberine, a natural alkaloid found in various plants like goldenseal and barberry, has been extensively studied for its diverse medicinal properties, showcasing potential benefits across several health domains. One prominent area of interest lies in its role in metabolic health. Berberine has demonstrated significant efficacy in managing diabetes and metabolic syndrome by improving insulin sensitivity, reducing blood sugar levels, and regulating lipid metabolism(1). These effects make it a valuable adjunct therapy for individuals with diabetes or those at risk of developing metabolic disorders.

Moreover, berberine exhibits notable anti-inflammatory properties (2). This attribute extends its potential therapeutic applications to conditions characterized by chronic inflammation, such as arthritis and inflammatory bowel disease. By modulating inflammatory pathways, berberine offers a natural alternative for alleviating symptoms associated with these ailments, potentially complementing existing treatment strategies.

Berberine's antimicrobial activity further enhances its medical utility (3). Research indicates its effectiveness against various pathogens, including bacteria, viruses, and fungi. This broad-spectrum antimicrobial action suggests berberine's potential in treating infectious diseases and underscores its role as a natural antimicrobial agent.

In addition to its metabolic and anti-inflammatory properties, berberine has emerged as a promising cardioprotective agent (4) . Studies have shown that berberine can help lower blood pressure, reduce cholesterol levels, and inhibit plaque formation in arteries, thus reducing the risk of cardiovascular diseases such as hypertension and atherosclerosis.

Berberine's neuroprotective effects have also garnered attention (5).

Research suggests its potential in mitigating neurodegenerative disorders like Alzheimer's and Parkinson's diseases. Its ability to modulate neuronal function and protect against neurotoxicity makes it a compelling candidate for further investigation in the realm of neurological health.

Furthermore, berberine has shown promise in cancer therapy (6). Preclinical studies have demonstrated its ability to inhibit cancer cell growth, induce apoptosis, and suppress tumor metastasis. While further clinical research is needed, berberine's multifaceted anti-cancer mechanisms present exciting prospects for its inclusion in cancer treatment regimens.

Weight management and obesity treatment represent another area of interest for berberine research (7). Studies have indicated its potential to reduce body weight, visceral fat accumulation, and improve metabolic parameters in overweight and obese individuals. These findings suggest berberine's role in addressing the global challenge of obesity and its associated health complications.

In summary, berberine exhibits a wide array of medical benefits, including its effects on metabolic health, inflammation, antimicrobial activity, cardiovascular health, neuro-protection, cancer therapy, and weight management. While much of the evidence supporting these benefits comes from preclinical studies, the accumulating research underscores berberine's potential as a versatile natural compound for promoting health and treating various diseases and conditions. Further clinical investigations are warranted to validate its efficacy, safety profile, and optimal therapeutic applications in clinical settings.

Note Well: The preferred genus and specie to get the most alkaloid per gram, best effect and best value, is Berberis Vulgaris. The Aristata Specie is not nearly as effective, although it is easier to find in most preparations. The real value is to look for the Vulgaris Specie.

Our typical regimen for Berberine:

For Diabetes and/or insulin resistance syndrome, we start with 500 mg twice daily, taken with food. Check blood sugar levels and adjust the dosage by an additional 500 mg until the blood sugar drops to the desired range.

Many patient experience loose bowel movements for the first few weeks, until the insulin and blood sugar levels equilibrate. Anticipate weight loss during this period to average 2-3 pounds per month, if you get the insulin below 10 and blood sugar below 90.


  1. Yin, J., Xing, H., & Li, D. (2008). Antidiabetic activities of aqueous extract from Berberis holstii and berberine in vivo and in vitro. Journal of Ethnopharmacology, 118(3), 479–484.

  2. Xu, D., Hu, M.-J., Wang, Y.-Q., & Cui, Y.-L. (2019). Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules, 24(6), 1123.

  3. Imenshahidi, M., & Hosseinzadeh, H. (2019). Berberis Vulgaris and Berberine: An Update Review. Phytotherapy Research, 33(3), 504–523.

  4. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., & Pan, H. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine, 10(12), 1344–1351.

  5. Ahmed, T., Gilani, A.-u.-H., & Abdollahi, M. (2015). Berberine and Neurodegeneration: A Review of Literature. Pharmacological Reports, 67(5), 970–979.

  6. Wang, N., Feng, Y., Zhu, M., Tsang, C.-M., Man, K., Tong, Y., & Tsao, S. W. (2019). Berberine Induces Autophagic Cell Death and Mitochondrial Apoptosis in Liver Cancer Cells: The Cellular Mechanism. Journal of Cellular Biochemistry, 120(4), 6616–6626.

  7. Zhang, H., Wei, J., Xue, R., Wu, J.-D., Zhao, W., Wang, Z.-Z., Wang, S.-K., Zhou, Z.-X., Song, D.-Q., Wang, Y.-M., & Pan, H.-N. (2018). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 59(2), 285–292.

1917 Boothe Circle

Longwood, Florida 32750

Tel: 407-679-3337

Fax: 407-678-7246


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